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NephroNet is a network of dedicated clinicians, investigators and affiliated sponsors that are collectively committed to advancing patient education, research and the realization of new methods to treat kidney disease.

💬 Reducing Therapeutic Nihilism in Chronic Kidney Disease (CKD)Far too often, patients with CKD are told what can’t be d...
08/31/2026

💬 Reducing Therapeutic Nihilism in Chronic Kidney Disease (CKD)
Far too often, patients with CKD are told what can’t be done rather than what can.
This editorial challenges that mindset — urging clinicians to move beyond therapeutic nihilism and embrace proactive, evidence-based management for kidney disease.
🩺 The message is clear:
➡️ CKD is not a lost cause.
➡️ Early intervention and personalized care can make a meaningful difference.
➡️ Empowerment and optimism must guide treatment strategies.
Read the full editorial in British Journal of Hospital Medicine:
📖 “Reducing Therapeutic Nihilism in Patients With Chronic Kidney Disease”

https://pubmed.ncbi.nlm.nih.gov/41134164/

🧠 New Research Insight: Steroid Withdrawal After Pancreas-Kidney TransplantCan steroids safely be withdrawn after simult...
08/27/2026

🧠 New Research Insight: Steroid Withdrawal After Pancreas-Kidney Transplant
Can steroids safely be withdrawn after simultaneous pancreas-kidney (SPK) transplantation?
A study of 307 SPK recipients found:
✅ No difference in rejection rates between steroid-withdrawal and steroid-maintenance groups (26% vs. 29%)
✅ Long-term outcomes were driven by rejection, not by steroid regimen
✅ Kidney rejection strongly predicted both kidney and pancreas graft survival
✅ Obesity was linked to higher risk of pancreas graft failure
🔍 Takeaway: For low-risk SPK recipients, early steroid withdrawal appears safe, with careful monitoring and individualized management.

https://pubmed.ncbi.nlm.nih.gov/41134310/

💡 New Study on Type 2 Diabetes and Lifestyle HabitsA nationwide analysis of 119,000+ U.S. adults with Type 2 diabetes re...
08/23/2026

💡 New Study on Type 2 Diabetes and Lifestyle Habits
A nationwide analysis of 119,000+ U.S. adults with Type 2 diabetes reveals an important truth:
🏃‍♀️ Even some physical activity and healthy eating go a long way.
📊 Key Findings:
• 37% of patients were physically inactive
• 53% ate ≤2 servings of fruits/vegetables daily
• Yet, even limited physical activity greatly improved:
✅ Self-rated health
✅ Cardiovascular outcomes
✅ Kidney health
👉 The takeaway: You don’t need to be perfect — small, consistent lifestyle improvements make a measurable difference.

https://pubmed.ncbi.nlm.nih.gov/41134496/

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🏃‍♂️💚 New study of 119K+ Americans with Type 2 diabetes shows:
Even modest physical activity = big health gains.
Inactive → “Good health” ↑ 2.6× with regular movement.
Perfection isn’t required—progress matters.

https://pubmed.ncbi.nlm.nih.gov/41134496/

🧠🩺 New Study Insight:Urinary tract infections (UTIs) remain the most common post-transplant infection—but not all kidney...
08/20/2026

🧠🩺 New Study Insight:
Urinary tract infections (UTIs) remain the most common post-transplant infection—but not all kidney transplant centers perform equally.
A review of 5,128 patients across 25 U.S. centers found UTI rates ranging from 0% to 12.9% within 30 days after surgery.
Key risk factors:
• Use of ureteral stents
• Longer catheter duration
• Female gender
• Older recipient age
➡️ The findings underscore the need for center-level collaboration to reduce complications and improve outcomes.

https://pubmed.ncbi.nlm.nih.gov/41134503/

🧬 Nanotechnology Meets Cancer Detection!A groundbreaking study explores how biomolecular coronas (BCs) — the unique prot...
08/18/2026

🧬 Nanotechnology Meets Cancer Detection!
A groundbreaking study explores how biomolecular coronas (BCs) — the unique protein layers that form around nanoparticles in the bloodstream — could be harnessed for early cancer diagnosis.
Researchers analyzed surface-modified polystyrene and silica nanoparticles with diverse functional groups (plain, NH₂, COOH) and found that BC signatures could distinguish healthy individuals from patients with cancer, and even differentiate cancer types such as ovarian and kidney cancer.
💡 Why it matters:
This fast, inexpensive, and minimally invasive method — requiring only a simple blood sample — could pave the way for personalized, first-line cancer diagnostics and post-treatment monitoring.
🧪 Study: “Study of the biomolecular corona of surface-modified polystyrene and silica nanoparticles: application to cancer.”

https://pubmed.ncbi.nlm.nih.gov/41134530/

🫀 New Insights from the CARE-HK in HF RegistryManaging patients with heart failure (HF) at high risk of hyperkalaemia re...
08/14/2026

🫀 New Insights from the CARE-HK in HF Registry
Managing patients with heart failure (HF) at high risk of hyperkalaemia remains a global challenge. The CARE-HK in HF multinational registry provides a detailed look at how these patients are managed in real-world clinical settings.
📊 Key Findings:
• 2,558 patients across 9 countries and 111 sites were followed prospectively
• 29% experienced a hyperkalaemic event during follow-up
• Only 29% received optimal RASi/MRA therapy, despite guideline recommendations
• Potassium binder use was limited (patiromer 9.1%, SZC 5.9%)
• Hyperkalaemia was associated with higher hospitalization risk (HR 1.59; p < 0.001)
💡 Conclusion: Hyperkalaemic events in HF are common and under-managed, leading to suboptimal therapy and increased hospitalizations. The registry highlights an urgent need for strategies to safely optimize RASi/MRA treatment in this population.
🔗 CARE-HK in HF Registry – ClinicalTrials.gov: [NCT04864795]

https://pubmed.ncbi.nlm.nih.gov/40788620/

🧠 Designing Clinical Trials for the Treatment of Membranous Nephropathy in the PLA2R EraMembranous nephropathy (MN) is a...
08/11/2026

🧠 Designing Clinical Trials for the Treatment of Membranous Nephropathy in the PLA2R Era
Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome — and with the discovery of the phospholipase A2 receptor 1 (PLA2R) autoantigen, nephrology has entered a new era of precision medicine.
The NephCure Membranous Nephropathy Workshop brought together top nephrologists, researchers, and industry leaders to chart the path forward for MN drug development.
🔬 Key Highlights:
• PLA2R autoantibodies are present in ~75% of MN patients
• The discovery enables personalized diagnostics, monitoring, and trial design
• Experts emphasized the integration of PLA2R biomarkers into future clinical trial endpoints
• Collaboration among academia, regulators, and patient advocacy groups is key to accelerating treatment innovation
💡 Precision nephrology is redefining how we design, test, and deliver therapies for autoimmune kidney diseases.

https://pubmed.ncbi.nlm.nih.gov/40092585/

🧬 Clinical Trial Spotlight: New Insights for Fibrillary Glomerulopathy (FGN)Fibrillary glomerulopathy is a rare kidney d...
08/06/2026

🧬 Clinical Trial Spotlight: New Insights for Fibrillary Glomerulopathy (FGN)
Fibrillary glomerulopathy is a rare kidney disease that can lead to end-stage renal disease in up to half of patients within two years. The FACT trial evaluated the efficacy and safety of repository corticotropin (Acthar® Gel) alone or in combination with tacrolimus in DNA-JB9 positive FGN.
📊 Key Findings:
• Acthar Gel alone significantly reduced proteinuria by >70% at 12 months (from 6.21 to 1.76 g/g; P < 0.02)
• Adding tacrolimus did not provide additional benefit in reducing proteinuria or improving eGFR
• Both regimens were well tolerated over the 12-month treatment period
✅ Conclusion: Acthar Gel represents an effective antiproteinuric therapy for patients with DNA-JB9 positive FGN—offering hope for an ultra-rare condition with limited treatment options.

https://pubmed.ncbi.nlm.nih.gov/40980649/

💊 Clinical Research Update: Promising Results in IgA Nephropathy TreatmentA new multinational phase 3 trial shows that a...
07/31/2026

💊 Clinical Research Update: Promising Results in IgA Nephropathy Treatment
A new multinational phase 3 trial shows that atrasentan, a selective endothelin type A receptor antagonist, significantly reduced proteinuria by 36% compared to placebo in patients with biopsy-proven IgA nephropathy — a condition linked to a high lifetime risk of kidney failure.
Importantly, atrasentan demonstrated strong efficacy and a favorable safety profile, with no reported cases of cardiac failure or severe edema.
🧠 These findings highlight the potential of atrasentan to become a meaningful therapeutic advancement for patients with severe proteinuria.
🔗 Learn more about the ALIGN study (NCT04573478) and the future of precision nephrology.

https://pubmed.ncbi.nlm.nih.gov/39460694/

🔮 Nefecon Predicted to Delay Kidney Failure in IgA Nephropathy 🧬A modeling analysis based on Phase 3 NefIgArd data sugge...
07/30/2026

🔮 Nefecon Predicted to Delay Kidney Failure in IgA Nephropathy 🧬

A modeling analysis based on Phase 3 NefIgArd data suggests nefecon could delay progression to kidney failure by up to 12.8 years in patients with IgA nephropathy.
📉 62% reduction in risk of major kidney outcomes
🧪 Median time to kidney failure:
• 22.4 years with nefecon
• 9.6 years with supportive care only
These results highlight nefecon’s long-term potential in preserving kidney function.

🔗 Learn more: https://ow.ly/Eufm50X4AaY

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