LabrulezLCMS-EN

Name: LabrulezLCMS-EN
Address: Pobřežní, Praha 8, 249, CZ
Telephone: +420724309027

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česko
Praha 8
LabrulezLCMS-EN

Everything from the world of Liquid Chromatography and Mass Spectrometry in one place. Stop searching and start finding.

17/09/2026

Heat-sensitive samples demand cold control. We compared two refrigerated centrifugal vacuum concentrators for integrity-first workflows: Labconco Refrigerated CentriVap vs Thermo Fisher Refrigerated SpeedVac SRF110. 🧪❄️

• Why refrigeration matters: evaporative cooling can freeze/sublimate samples; precise set-point prevents it. 🧊🎯
• Throughput: CentriVap up to 312 samples/run vs SRF110 132; both handle up to 50 mL. 🚀
• Temperature: down to -10°C vs -4°C; both up to +100°C. 🌡️
• Speed control: 500–1,800 rpm vs up to 1,725 rpm for gentler handling. ⚙️
• Visibility: glass lid (CentriVap) vs epoxy-coated aluminum (SRF110). 👀
• Price: ~$13K (CentriVap) vs $15K–$17K+ modular kit (SRF110). 💸
• Footprint/warranty: comparable 1-year. 📦✅

Bottom line: For peptide therapeutics and busy core facilities, CentriVap offers higher throughput, a colder floor, and stronger value. Organomation distributes the full Labconco CentriVap line—reach us at [email protected]. 🤝

Download the full comparison with pricing: https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac

Compare Labconco Refrigerated CentriVap and Thermo Fisher SpeedVac SRF110 by capacity, temperature range, price, and flexibility.

17/09/2026

🧬⚡ Meet Atomic Charge Calculator III: molecular electrostatics, simplified.

• What it does: calculates partial atomic charges and maps them onto interactive 3D structures via Mol*—from small molecules to proteins. 💻🔬
• Why it matters: clarifies how molecules attract/repel and bind—e.g., oseltamivir (Tamiflu) with influenza A neuraminidase, and the SARS‑CoV‑2 pore complex. 💊🦠
• Easy access: run in your browser—no install or signup. Visualize instantly; download results (incl. mmCIF). For scale, use the API or run the core locally. ☁️⚙️🗂️
• Built by CEITEC Masaryk University, Faculty of Science MU, Faculty of Informatics MU, and Palacký University Olomouc. Developed by Tomáš Raček; long-term effort at CEITEC highlighted by Radka Svobodová. 👨‍🔬👩‍🔬
• Recognized in Nucleic Acids Research (Web Server Issue cover). Supported by ELIXIR CZ. 🏆

Try it: https://acc.biodata.ceitec.cz/
Paper: https://academic.oup.com/nar/article/54/W1/W211/8662890

ACC III from CEITEC Masaryk University calculates and visualises partial charges, helping researchers understand molecular interactions in 3D structures.

16/09/2026

Charged for success ⚡ Ion Exchange Chromatography (IEX) separates ionizable molecules by charge—delivering high resolution, scalability, and affordability.

• Why it stands out: handles large sample volumes 💪, broad biomolecule coverage (enzymes, proteins) 🧪, powerful resolving power 🎯, automation-ready 🤖, simple scale-up 📈, moderate costs 💲
• How it works: reversible exchange between mobile phase and a charged stationary phase 🔁 — cation exchange (− groups bind cations) ➕ and anion exchange (+ groups bind anions) ➖
• Workflow: equilibrate ⚙️, load 📥, wash 🚿, elute via salt or pH gradient 🌈, collect/analyze (UV/MS) 🔬
• Applications: protein/enzyme purification, nucleic acids, amino acids, metabolites; pharma QC and biopharma; water treatment; food & beverage 🌍
• Watch-outs: sensitivity to pH/ionic strength ⚠️, high-salt or extreme pH can denature biomolecules 🧯, finite capacity and longer gradients ⏳

Explore the technique: https://www.phenomenex.com/techniques/hplc-ion-exchange

Ion exchange chromatography (IEX): how charge-based separation works, key applications, advantages, and limitations of this technique.

16/09/2026

🌶️🧪 What gives ginger its kick? An HPLC comparison of fresh root, tea, and commercial ginger shots reveals the chemistry behind the heat. 🧬🍹

• Fresh ginger delivered the strongest [6]-gingerol reference. 🌱🔥
• Classic and pomegranate shots showed the highest [6]-gingerol and a broader profile with [8]-gingerol, [10]-gingerol, and [6]-shogaol. 💥
• Vitamin Acai and pineapple were similarly broad. 🍍
• Turmeric and fruit shots were [6]-gingerol–dominant; the fruit shot was lowest (declared 2% ginger). 🍊
• Hot-water ginger tea gave only a small signal vs methanol/water extracts. 🍵
• Method: reversed-phase HPLC on a KNAUER Eurospher II C18H column; results are comparative (signal heights), not quantitative. 🔬

Takeaway: processing transforms gingerols into shogaols—and simple RP-HPLC shows what’s really inside. As William Shakespeare knew, ginger has lasting appeal. ✍️

Download the I.N.G.W.E.R. application note:https://labrulez.com/pdf/I_N_G_W_E_R_Analytica_254b7c26e3.pdf

See how reversed-phase HPLC reveals gingerols and shogaols in fresh ginger, tea, and commercial ginger shots using a KNAUER C18 column.

16/09/2026

LC/MS community, your weekly drop is here! 🚀 Explore the newest additions to the LabRulezLCMS Library (week of Sep 14, 2026) 🔬📚

• Agilent Technologies: Altura Ultra Inert PLRP‑S 1000 Å boosts intact protein/peptide RP‑HPLC‑MS—15× faster passivation, ~10% higher recovery for mAbs/ADCs, up to 100% for GLP‑1s/small proteins. 💪🧪
• Shimadzu / AOAC: DCDI ambient ionization on LCMS‑2050 captures retronasal aroma during gummy chewing—real‑time, texture‑dependent release mapping for flavor science. 🍬👃⏱️
• Thermo Fisher Scientific / Metabolomics: Orbitrap Tribrid + Real‑Time Library Search (mzCloud) guides ddMS3 for smarter unknown tea metabolite characterization—shared sub‑structure insights. 🍵🧠
• Waters Corporation: Capillary UHPLC‑MS/MS quantifies GLP‑1 RAs with 10× sensitivity (down to 20 pg/mL), robust >500 injections, reduced solvent—no complex nanospray. 📈💉

Dive in: https://lcms.labrulez.com/library

This week we bring you application notes by Agilent Technologies and Waters Corporation and posters by Shimadzu/AOAC, Thermo Fisher Scientific/Metabolomics.

15/09/2026

PFAS testing is shifting fast—and labs must keep pace. 🌍🧪

• Europe is widening oversight from drinking water to surface/groundwater, soil, packaging and industrial emissions. 🇪🇺
• Since Jan 2026, EU states monitor PFAS in drinking water; stricter controls follow via the Industrial Emissions Directive (PFOA, PFHxS from 2028) and the EU Water Framework Directive (incl. TFA). 📑
• Matrices now span water, wastewater, food, cosmetics and industrial goods—demanding tailored prep, targeted quant, and broader screening like TOF and combustion ion chromatography. 🔬
• Innovation in action: Severn Trent Laboratories (Bridgend, UK) adopted DLLME to cut handling and solvents—an agile alternative to SPE. ♻️

Ready to adapt?
• Dive into PFAS resources and webinars: https://gateway.on24.com/wcc/eh/4080611/category/139628/pfas-testing?partnerref=E.25CMD.EL102.26305.01
• Watch the Severn Trent webinar: https://labrulez.com/en-us/all/webinar/6542

Explore how PFAS testing is evolving across water, food and industrial samples, with new regulations, DLLME workflows and broader analytical approaches.

15/09/2026

• ISC 2026 closed in Prague with a high‑energy finale of separation science. 🎉🇨🇿
• AI/ML in chromatography stood out: entropy‑driven LC optimization (Bob W.J. Pirok, University of Amsterdam) and operator‑free siRNA method development (Edward Ahearne, AstraZeneca). 🤖📈
• Forensics & security advanced with sports drug testing (Mario Thevis, German Sport University Cologne) and CWA verification (Jakub Milczarek, OPCW). 🛡️🧪
• Miniaturization, 3D printing, and powerful LC/GC workflows fueled breakthroughs—plus deep glycoproteomics insights (Christian G. Huber, University of Salzburg). 🧩🧬
• Plenary: Ana M. Garcia‑Campaña (University of Granada) mapped chemical exposomics from food safety to human biomonitoring. 🍽️🧍‍♀️
• Congrats to Pavel Jandera Awardees: Bram Huygens, Marie Pardon, Christian Geibel. Chairs Michal Holčapek and Lucie Nováková closed the event—see you at ISC 2028 in Spain! 🏆🇪🇸

ISC 2026 Day 5 featured AI, bioanalysis, forensics, 3D printing, glycoproteomics, GC×GC/MS, exposomics, award winners, and the Closing Ceremony.

15/09/2026

🚀 Beyond exact matches in MS/MS: James Little (Mass Spec Interpretation Services) shows how NIST26 Hybrid Search turns library hits into structural insight.

• 🔍 Hybrid MS/MS Search in the NIST Mass Spectral Search Program recognizes related compounds via mass differences, dForm, and pctRefForm—linking spectra to plausible chemical modifications.
• ⚙️ Two modes: manual (Library Search window) for deep dives and automated (Chromatogram workflow) for high-throughput screening—stronger together.
• 🧪 PEG case study: an (M+NH4)+ adduct with NH3 loss led to PEG ether candidates; dForm matched three ethylene glycol units (132.079), confirmed with the NIST MS Interpreter.
• 💡 Tip: when you see (M+NH4)+, search with the (M+H)+ value—major fragments often align with NIST MS/MS Library spectra.
• 📈 Result: move from “Is it in the library?” to “How does my unknown differ from the closest known structure?”

🔗 Smarter workflows, richer identifications, and faster paths to chemically meaningful answers with NIST26.

Explore NIST26 Hybrid MS/MS Search for unknown identification using spectral similarity, dForm, fragmentation, and automated chromatogram workflows.

14/09/2026

🔬 Toward truer LC–MS/MS quantitation! This study shows slope-only matrix-effect checks can miss concentration-independent “translational” bias—and unveils an intercept-based equation that, combined with slope, captures the full picture. 📈

• What’s new: a robust intercept + slope strategy covering rotational and translational matrix effects 💡
• Why it matters: slope-only often underestimates ME; the combined metric tracks post-extraction addition (Matuszewski) closely ✅
• How tested: 26 compounds in serum; validated in plasma, urine, and apple juice on Waters Xevo TQ‑XS and Agilent 6495 🧪
• Impact: more reliable validation and fewer extra experiments; platform-agnostic and robust across common weighting schemes (non-Ln) 🚀
• Proof: at LLOQ, slope-only errors reached thousands %, while the new approach stayed within ±20% of reference (e.g., 17α‑hydroxyprogesterone: +391% vs −31%; new: +374%) 📊

By Hana Kočová Vlčková, Kateřina Plachká, František Švec, Lucie Nováková. Analytica Chimica Acta (2026). DOI: https://doi.org/10.1016/j.aca.2026.345642

UHPLC-MS/MS study shows that calibration slope alone can underestimate matrix effects and proposes an intercept-based correction for reliable quantification.

14/09/2026

Your LC/HPLC/LC–MS calendar is packed! Sep 14–18, 2026 (CEST) brings 19 power webinars from Agilent Technologies, Thermo Fisher Scientific, Waters Corporation, C&EN, and SelectScience. 🚀

• 🧬 Targeted methylation sequencing for clinical epigenetics (Agilent Technologies)
• 🧱 Monodisperse polymeric particles boosting RP separations for oligos & RNA (Thermo Fisher Scientific)
• ☕ Strategies to beat LC carryover for robust, reproducible analyses (Waters Corporation)
• 🤖 Fast-track closed-loop AI automation on Stuntman (C&EN)
• 🧪 Proteomics at scale powering precision health and discovery (Thermo Fisher Scientific)
• 🌊 PFAS monitoring in wildlife by LC-MS/MS + EFOX for smarter environmental workflows (Thermo Fisher Scientific)
• 🏥 Digital QA/QC and inspection-ready labs (SelectScience)
• 🔬 Cary 3500 UV-Vis, SEC column insights, and practical IEX–MS for biotherapeutics (Agilent Technologies, Thermo Fisher Scientific)
• 🧯 Polysorbate analysis, EV profiling with Leprechaun (North Texas Eye Research Institute), oligo CGE, and MAM readiness (Waters Corporation, SelectScience)

• 🔎 Search 6,000+ GC/LC/MS & spectroscopy webinars
• 🔗 Details & registration: https://lcms.labrulez.com/webinars

19 webinars: biopharma QC, CGE, EFOX, GLP-1, IEX-MS, LC-MS/MS, MAM, methylation sequencing, PFAS, proteomics, SEC, SureSelect, UV-Vis

Adresa

Pobřežní
Praha 8
249

Telefon

+420724309027

Internetová stránka

https://lcms.labrulez.com/

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