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10/09/2023

Beneficial properties, making them ideal candidates for the development of various novel therapeutic strategies.

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10/09/2023

I will discuss some of the key advantages of these technologies over more traditional therapeutic compounds. Targeting Undruggable Targets

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10/09/2023

including antisense RNA and siRNA, play an important role in the pathogenesis of human diseases through sequence-specific binding

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10/09/2023

including antisense RNA and siRNA, play an important role in the pathogenesis of human diseases through sequence-specific binding
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10/09/2023

This review describes how splicing in RNA biology can be regulated by antisense oligonucleotides (ASOs)39. Fomivirsen was the first

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10/09/2023

for the treatment of giant cell leukemia, which is critical for CMV replication 10 . However, the drug was withdrawn by the FDA in

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10/09/2023

Protein functionality is limited, and less than one-third of human proteins can be effectively targeted by small molecules

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10/09/2023

The second group of antisense oligonucleotide drugs is mainly used in the pass-through mode 47 , 48 . A second
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10/09/2023

People with spinal muscular atrophy, a rare neuromuscular disease, have mutations in the SMN1 gene, which encodes motor neuron

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10/09/2023

This shortened dosing cycle can improve compliance, reduce costs, and reduce toxicity, highlighting

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10/09/2023

Aptamers Aptamers are nucleic acid constructs designed to bind to specific proteins to modulate

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10/09/2023

This aptamer is designed to bind to an isoform of vascular endothelial growth factor (VEGF)165 and block its interaction

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