Hybrid Medical Animation

11/20/2024

11/10/2023

We love our new space! We had a great experience building out our new office with Doran.

11/02/2023

This animation delves deep into the tumor microenvironment (TME) — a complex cellular domain in which a tumor resides.

Take an immersive, cinematic journey through this thriving tumor microenvironment, showcasing the intricate biological landscape of an extracellular matrix, newly-forming blood vessels, cancer-associated fibroblasts, and various immune cells such as macrophages, T cells, B cells, dendritic cells, neutrophils, NK cells, and more.

Tumors are more than just masses of malignant cells. Although the composition of the TME varies between tumor types, in many cases, the actual tumor cells might comprise less than half of the tumor's total mass. Our animation also highlights the newly-formed vasculature. These vessels not only sustain the TME with oxygen and nutrients but also provide a route for tumor cells to access the bloodstream and potentially metastasize to distant sites.

In this exploration, we also emphasize cell migration — a critical, multifaceted process shaped by various factors. Cells within the TME communicate with each other through an intricate network of signaling pathways that can influence immune response and surveillance, angiogenesis, tumor growth, metastasis, and resistance to therapies. There have been recent advancements in understanding the spatial arrangement and complex interrelationships of cells in the tumor microenvironment.

Ultimately, a tumor's growth and potential to spread are shaped by several intertwined pathological events, including chronic inflammation, alterations and remodeling of the extracellular matrix, angiogenesis, immune system suppression, and cell migration.

01/17/2023

A new collection of some of our favorite and latest work, featuring segments from medical animation projects we have produced over the past couple of years.

This latest showreel reflects our passion, expertise, and dedication to excellence over the 23 years we’ve been around.

Hybrid creates high-end 3D animation and augmented reality for science & biology educators and medical marketing professionals engaged in the fields of healthcare, biotechnology & medicine.

05/03/2022

Cytotoxic t cells targeting tumor cells | immunotherapy | tumor cell death animation

A close-up fly-through of tumor cells, and the arrival of cytotoxic t cells intent on eradicating them.

A key challenge we were given for this sequence: develop a rendering approach that mimics infrared thermal microscopy imaging techniques.

Researchers have been making advancements in understanding the thermal behavior of cells – for example, the ability to read the signatures of tumor cells due to their higher metabolism – in order to be used alongside existing histological analysis methods.

03/14/2022

Sequence from immersive 1.5-minute 360° animation (for WebMD) where we explore the benefits of sleep.

Here within the neural microspace of the brain, we depict the “cleansing system” of the brain: the glymphatic system.

Just like the rest of your body, the brain accumulates waste. Recent discoveries have shown that cerebral spinal fluid “flushes” debris and metabolic toxins out of the neural microspace during the deep sleep phase.

We also watch the heart beating (and lungs breathing) inside the chest cavity and discuss the role of sleep in reducing your risk for cardiovascular diseases.

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11/09/2021

Deep in the lungs, we can see the clusters of tiny air sacs -- the alveoli -- becoming inflamed and filling with pus, making it difficult to breathe.

08/20/2021

Selected segments from virtual experience created for the SDEF 20th Annual Las Vegas Dermatology Seminar. The immersive 360 virtual experience was viewed -- simultaneously -- by over 300 participants.

This is recorded footage of the virtual experience from inside the VR headset. The presentation was given by an internationally recognized expert in psoriasis.

08/19/2021

Patient education animations created for WebMD that explore common medications for type 2 diabetes.

Because each treatment works in a unique way, our task was to bring three medications to life, creating an easy-to-understand mechanism of action story for each science story.

The three medications highlighted on the WebMD website: Metformin, Dipeptidyl Peptidase-4 (DPP-4), and SGLT2 Inhibitors.

These are selected segments from the larger productions.

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04/02/2021

Sequence from animation that takes a closer look at adenoviral vector technology and the advancements being made with the creation of the Oxford-AstraZeneca vaccine for Covid-19.

We constructed and assembled the structure -- from the icosahedral capsid to other principal components including the penton bases, the hexons, and fibers -- by working with cryo-electron microscopic and crystallographic data.